Pharmacogenomics (PGx) Translation Service
"It’s far more important to know what person the disease has than what disease the person has"
(c. 460 bc - c. 375 bc)
ePGA: Purpose and Use
ePGA TRANSLATION SERVICE IS SOLELY FOR RESEARCH,
DEMONSTRATIONAL & EDUCATIONAL PURPOSES
ePGA Translation Service is meant to DEMONSTRATE the potential of translating validated PGx knowledge into clinical practice
In its current implementation ePGA Translation Service use just public-domain and completely anonymous genotype profiles
from the 1000 Genomes project (Phase I/1092 sample cases, Phase III / 2504 sample cases) in order to demonstrate its functionality
- The ePGA Translation Service adheres to the emerging trend of pre-emptive high-throughput genotyping as a vital clinical (diagnostic and prognostic) decision making component
aiming to offer respective genotype-to-phenotype inference services as a mean to translate PGx knowledge from bench-to-bedside.
- The ePGA Translation Service is based on ‘matching’ individual genotype (SNP) profiles with PGx gene haplotypes, and the subsequent inference of the corresponding metabolizer
phenotypes. Currently ePGA/Translation component employs harmonized haplotypes-tables as registered and curated by PharmGKB (the most advanced PGx knowledge base).The developers of ePGA are planning to expand the system in order to capture and cover PGx knowledge from other sources as well.
- ePGA developers reserve the right at any time, to make changes to the whole or any part of the services offered on this Web-site as it deems appropriate.
ePGA Translation considers the entire list of SNPs.
Custom Translation considers only the list of SNPs uploaded.
Gene Summary is based on ePGA(FULL) Translation.
Sample Summary is based on ePGA(FULL) Translation.